Karlstad, Växjö , Kalmar and Ängelholm are locations also hit by the slew of withdrawals.
According to a report in the local Värmlands Folkblad daily the only Swedish airports to escape the cut-backs are Malmö, Jönköping and Skellefteå.
The airline will leave Karlstad airport entirely after cutting its route to Barcelona.
"Very sad , but we hope they can come back in 2015," airport manager Peter Landmark told Värmlands Folkblad.
Some 23 flights a week will be removed from schedules out of Skavsta Airport in Nyköping, the airline's main gateway to Stockholm. Six major destinations including Frankfurt, Hamburg, Düsseldorf and Berlin disappear completely, according to local media reports.
"It is very sad news for all of us. We are trying to manage it as best we can," said Skavsta CEO Dot Gade Kulovuori to Södermanlands Nyheter.
The cutbacks are not connected to the recent spate of negative media reports affecting the firm, but are instead due to several commercial factors. These include the displacement of a large number of aircraft to Ireland, following the removal of a flight tax.
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The company is furthermore in the process of replacing its fleet of aircraft and deliveries of new planes is reported to have been delayed until the end of 2014.
Ryanair has also announced plans to start flying domestic routes in Italy, which has meant that a number of planes have been relocated there.