New test reveals risks for pregnant women
Published: 7 Apr 10 08:38 CET | Print version
Online: http://www.thelocal.se/25936/20100407/
Swedish researchers have discovered a new way of establishing at an early stage which women run the risk of toxaemia (pre-eclampsia) during pregnancy.
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Researchers at the biomedical centre at Lund University Medical Faculty have identified two substances - foetal haemoglobin and Alpha-1 microglobulin - which can be measured in the blood several months before the first symptoms emerge.
The method has been tested in blind studies on 96 English women with genetic tendencies towards a high risk for toxaemia. The Lund researchers were able to establish with a 90 percent certainty which of the women would suffer from the condition.
The researchers have also developed a possible treatment for the illness.
The Alpha-1 protein, which is used by the body to protect against injury, can also be used to treat the sick women, preliminary tests have shown. When injected into the the placenta all traces of toxaemia were found to have disappeared.
Pregnancy toxaemia or pre-eclampsia is a condition which affects around two percent of pregnant women in Sweden. The condition is accompanied by high blood pressure and protein in the urine and can harm the transfer of nutrients from the placenta to the unborn child, causing stunted growth.
More serious cases can lead to seizures (eclampsia), cerebral haemorrhaging, several other serious conditions and even death, but that is very rare in Sweden due to regular pre-natal checks.
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Anyone?
The blood tests such as the triple test don't actually tell you if there is a chromosone abnormality - they give you a risk factor - those who have a high risk factor are offered amnicentesis - although they give a lot of false positives as anything up to one chance in 250 is regarded as 'high risk' whereas 249 will not have an abnormality. I have a relative in the UK who was preganant at 43 who refused an amnio following 'high risk' blood results when she found out her risk factor was around 1:240 whereas the miscarriage risk for the amnio was 1:100
The more modern test that is given in some areas is a nuchal fold ultrasound scan which can be done at around 11-13 weeks and again gives you a risk factor for downs syndrome - however not all health authorities have this test yet