One of the cars had come onto the motorway on the wrong side and was heading north on the southbound carriageway.
The drivers in both the cars involved were alone. The driver travelling in the wrong direction died, said police, while the other is injured. It is not known how serious the injuries are.
The crash was first spotted by a police unit which was on its way to another road accident, outside Bjuv, in which several people were reported injured.