Arsenal manager Arsene Wenger has already expressed concern about England coach Roy Hodgson's decision to call up Gunners midfielder Jack Wilshere, who only recently returned from a 17-month injury lay-off.
Ferguson, who has four players in the England squad, says he can sympathise with the Frenchman.
"Friendly games at this time of year don't mean a thing to me," he said.
"It won't be a full squad anyway because players will drop out. I can understand where Arsene is coming from with that (Wilshere complaint).
"When you are out for a long period and play your first game, the adrenaline helps you.
"But there is a physical reaction a few days later. You never know after someone has been out for so long."
Wilshere himself has admitted that his international recall may have arrived "too soon". The 20-year-old Arsenal playmaker has only recently returned to action following more than a year out of the game.