One person was also left seriously injured with three others treated for minor injuries at Örebro University Hospital, it was confirmed on Wednesday afternoon.
The accident took place in the morning close to the town of Mogetorp.
Emergency services were already in the area after another car slid off the road.
According to police, the two trucks were travelling in different directions when the accident happened.
The collision also led to a fire truck and an ambulance being pushed into a nearby ditch.
The road was closed in both directions, with alternative traffic diversions in place by 2pm.
Police said it was snowing at the time of the accident, but could not be sure if this was the cause of the crash.
Emergency services at the scene. Photo: TT
Örebro is one of the regions that was issued with a class one snow warning on Wednesday. The highest possible warning is a three.
While snow is common in Sweden in winter, national weather agency SMHI only issues warnings when there is a chance that it could cause dangerous conditions.
“It will snow for a long time and it will be a continuous snowfall. Most snow will fall on the day [Wednesday] and slow down tomorrow,” Sandra Andersson, a meteorologist at SMHI told the TT news agency.