• Sweden's news in English
 
app_header_v3

Hereditary disease 'random': Swedish study

Oliver Gee · 10 Jan 2014, 15:39

Published: 10 Jan 2014 15:39 GMT+01:00

The study, which was published in the journal Science, homed in on single cells to investigate their gene activities, rather than pooling hundreds of thousands of cells and working with averages as has been common practice. 
 
Previous studies led researchers to believe that both gene copies (those from the mother and father) are used to the same extent in the cells of the human body, whereas the new Swedish study found that gene activity is much more dynamic and unpredictable.
 
The results may explain why people get afflicted by a hereditary illness while their relatives remain healthy, or why identical twins don't always look identical, explained study leader Doctor Rickard Sandberg.
 
"By developing these methods to measure all gene activities from single cells, we see that there is a much more dynamic pattern," he told The Local. 
 
Following the cells individually allowed scientists a closer look at these patterns and what they meant.
 
"You can follow the dynamics of gene expression of both gene copies as they become active, and contrary to what people expected, not both are active in each cell all the time."
 
He added that the ability to zoom in on a cell may improve cancer research, as researchers can now monitor the few cells that escape from primary tumours into the blood stream and lymph fluids.
 
Story continues below…
"Normally you'd have to pool hundreds of thousands, even millions, of cells to find out more," Sandberg explained.
 
Sandberg undertook the study to satisfy an interest in understanding how genes are regulated in our cells, their uses, and their unique functions. 
 
The research was conducted at the Karolinska Institutet and the Ludwig Institute for Cancer Research and was financed through grants from the European Research Council, the Swedish Research Council, the Swedish Foundation for Strategic Research and the Åke Wiberg Foundation.

Related links:

Oliver Gee (oliver.gee@thelocal.se)

Your comments about this article

Today's headlines
Why northern Swedes get the hots for sex toys
File photo of handcuffs. Photo: Gunnar Lundmark/SvD/TT

Where in Sweden do people buy the most sex toys? Kiruna in the far north, apparently.

Royal baptism day for Sweden's Prince Oscar
Prince Oscar with Archbishop Antje Jackelén. Photo: Jonas Ekströmer/TT

UPDATED: Royalty, dignitaries and other esteemed figures took to Stockholm's Royal Chapel for the ceremony.

Giant replica of Swedish 18th century ship up for sale
The Götheborg setting sail from Stockholm in 2008. Photo: Claudio Bresciani / TT

A replica of a doomed Swedish merchant vessel that sank in 1745 within sight of its home port of Gothenburg has been put up for sale.

Video
The top reactions to Swedish high heels handyman video
Andersson was in agony after a day of laying floors in high heels. Photo: Emil Andersson

What did The Local's readers think about this viral clip challenging sexist beauty ideals?

Border checks
First migrants make it from Denmark to Sweden on foot
The Öresund bridge between Sweden and Denmark. Photo: Erland Vinberg/TT

Dozens of attempts have been made, but this is the first successful crossing since Sweden introduced ID and border checks.

Brexit
Poll: Swedes are worried about Brexit consequences
The possibility of Brexit has Swedes worried about the EU's future. Photo: Lars Pehrson/SvD/TT

Swedes are worried about what may happen both at home and abroad if Britain votes to leave the EU in June.

The Local Recipes
Fend off the bad weather with a Swedish beetroot salad
Beetroot salad with cumin and feta. Photo: John Duxbury/Swedish Food

Rain, rain, go away.

How a Swedish rocker saved the life of this cute baby elk
Erik Brodén's daughters Tyra and Brita with the elk baby. Photo: Private

Probably the sweetest story you'll read today.

Man sentenced over dinner party murder in west Sweden
The man during a preliminary court hearing last year. Photo: Björn Larsson Rosvall/TT

He stabbed his friend at a dinner party and attempted to kill two others.

The Local List
Ten reasons why Varberg is the best place in Sweden
The Local shows some love for Varberg. Photo: Mikael Pilstrand/MarknadVarberg

Forget Stockholm, Gothenburg or Malmö, it looks like seaside town Varberg is Sweden's place to be.

Sponsored Article
How to find student housing in Malmö: 5 tips
Gallery
The best, cutest and funniest snaps from Prince Oscar's christening
Sponsored Article
Can you afford to live in Stockholm? (Hint: yes)
Travel
Is this town the best place in Sweden?
Gallery
People-watching: May 25th
Blog updates

27 May

Editor’s blog, May 27th (The Local Sweden) »

"Hej readers, Would you spend a day doing manual labour in high heels? That’s what Swedish…" READ »

 

17 May

What about “att”? (The Swedish Teacher) »

"Hej! It often seems like the small words are the ones that cause the most confusion.…" READ »

 
 
 
Sponsored Article
'Sweden gives artists the space to follow their dreams'
Society
WATCH: Why Swedish handyman wore pink high heels for feminism
Sponsored Article
Stockholm makes it easier for refugees to meet startups
Sport
LIST: Top-ten ridiculous things Zlatan has compared himself to
Business & Money
Why Swedes don't want the euro
Fastighetsbyrån
Gallery
Property of the week: Vika, Falun
Sponsored Article
Food, fun, and reliable sun: Summer in Dubrovnik
National
Is this the most Swedish tattoo ever?
Sponsored Article
How Stockholm startups help new employees feel at home
Gallery
People-watching: May 20th-22nd
National
How to really annoy a Swede abroad
Sponsored Article
'Only soft power can defeat radicalism'
National
How this war veteran is warming hearts in Sweden
Sponsored Article
Why Stockholm attracts so many successful researchers
Gallery
People-watching: May 18th
National
How this Swede's viral ad totally nailed Stockholm's housing crisis
Gallery
Property of the week: Vasastaden, Gothenburg
Sponsored Article
'Sweden gives artists the space to follow their dreams'
Lifestyle
The best Swedish cities for dating
Sponsored Article
Retiring abroad: ensuring your health is covered
Gallery
People-watching: May 13th-15th
Sponsored Article
Can you afford to live in Stockholm? (Hint: yes)
Culture
BLOG: Eurovision as it happened
National
Why a 116-year-old Swede isn't the world's oldest woman
National
Youth unemployment falls in Sweden
Gallery
People-watching: May 11th
Gallery
People-watching: May 6th-8th
Politics
Why Sweden's Greens are in free fall
National
Can these cartoon Swedes help foreigners blend in?
3,348
jobs available
PSD Media
PSD Media is marketing company that offers innovative solutions for online retailers. We provide modern solutions that help increase traffic and raise conversion. Visit our site at:
psdmedia.se