A third man is seriously, but not critically, injured, according to the Gävle hospital.
The victims are between 25 and 35-years -old.
Police received an emergency call about 11.30pm. According to witnesses, one person had at the time been stabbed on Skolgatan in Sandviken while someone else chased a second man with a knife.
A short time later, three injured men were taken to Gävle hospital.
Throughout the night, police have knocked on doors in the area, interviewed witnesses, and blocked off three different locations on Skolgatan.
As of four o’clock on Friday morning, police still had no information as to what may have caused the fight.
An investigation has been launched and the crime has been classified as an aggravated assault.